Biomechanical regulation of drug sensitivity in an engineered model of human tumor.
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ABSTRACT:
SUBMITTER: Marturano-Kruik A
PROVIDER: S-EPMC5660643 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Publications
Biomechanical regulation of drug sensitivity in an engineered model of human tumor.
Marturano-Kruik A A Villasante A A Yaeger K K Ambati S R SR Chramiec A A Raimondi M T MT Vunjak-Novakovic G G
Biomaterials 20171010
Predictive testing of anticancer drugs remains a challenge. Bioengineered systems, designed to mimic key aspects of the human tumor microenvironment, are now improving our understanding of cancer biology and facilitating clinical translation. We show that mechanical signals have major effects on cancer drug sensitivity, using a bioengineered model of human bone sarcoma. Ewing sarcoma (ES) cells were studied within a three-dimensional (3D) matrix in a bioreactor providing mechanical loadings. Mim ...[more]
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