Cerebral amyloid angiopathy in Down syndrome and sporadic and autosomal-dominant Alzheimer's disease.

ABSTRACT: INTRODUCTION:We aimed to investigate if cerebral amyloid angiopathy (CAA) is more frequent in genetically determined than in sporadic early-onset forms of Alzheimer's disease (AD) (early-onset AD [EOAD]). METHODS:Neuroimaging features of CAA, apolipoprotein (APOE), and cerebrospinal fluid amyloid ? (A?) 40 levels were studied in subjects with Down syndrome (DS, n = 117), autosomal-dominant AD (ADAD, n = 29), sporadic EOAD (n = 42), and healthy controls (n = 68). RESULTS:CAA was present in 31%, 38%, and 12% of cognitively impaired DS, symptomatic ADAD, and sporadic EOAD subjects and in 13% and 4% of cognitively unimpaired DS individuals and healthy controls, respectively. APOE ?4 genotype was borderline significantly associated with CAA in sporadic EOAD (P = .06) but not with DS or ADAD. There were no differences in A?040 levels between groups or between subjects with and without CAA. DISCUSSION:CAA is more frequently found in genetically determined AD than in sporadic EOAD. Cerebrospinal fluid A?40 levels are not a useful biomarker for CAA in AD.

SUBMITTER: Carmona-Iragui M 

PROVIDER: S-EPMC5660938 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature