Ontology highlight
ABSTRACT:
SUBMITTER: Wang R
PROVIDER: S-EPMC5661113 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Journal of cellular and molecular medicine 20170613 11
Higher and prolonged viral replication is critical for the increased pathogenesis of the highly pathogenic avian influenza (HPAI) subtype of H5N1 influenza A virus (IAV) over the lowly pathogenic H1N1 IAV strain. Recent studies highlighted the considerable roles of cellular miRNAs in host defence against viral infection. In this report, using a 3'UTR reporter system, we identified several putative miRNA target sites buried in the H5N1 virus genome. We found two miRNAs, miR-584-5p and miR-1249, t ...[more]