Alternations of White Matter Structural Networks in First Episode Untreated Major Depressive Disorder with Short Duration.

ABSTRACT: It is crucial to explore the pathogenesis of major depressive disorder (MDD) at the early stage for the better diagnostic and treatment strategies. It was suggested that MDD might be involving in functional or structural alternations at the brain network level. However, at the onset of MDD, whether the whole brain white matter (WM) alterations at network level are already evident still remains unclear. In the present study, diffusion MRI scanning was adopt to depict the unique WM structural network topology across the entire brain at the early stage of MDD. Twenty-one first episode, short duration (<1 year) and drug-naïve depression patients, and 25 healthy control (HC) subjects were recruited. To construct the WM structural network, atlas-based brain regions were used for nodes, and the v

SUBMITTER: Lu Y 

PROVIDER: S-EPMC5661170 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature