Ontology highlight
ABSTRACT:
SUBMITTER: Guo WY
PROVIDER: S-EPMC5661287 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Guo Wei-Yi WY Zhu Li L Meng Si-Jun SJ Shi Su-Fang SF Liu Li-Jun LJ Lv Ji-Cheng JC Zhang Hong H
Journal of the American Society of Nephrology : JASN 20170711 11
IgA nephropathy (IgAN) is characterized by infections followed by episodic gross hematuria. Deficiency of mannose-binding lectin (MBL) is associated with recurrent infection in many diseases, but controversy exists regarding the role of MBL in IgAN. Here, we measured <i>MBL2</i> variants and MBL levels in 749 patients with IgAN and 489 healthy controls. Overall, 5.2% (39 of 749) of patients with IgAN had MBL deficiency (MBL levels <100 ng/ml), among whom LYPB/LYPB and LXPA/LYPB were the predomin ...[more]