MnTBAP Inhibits Bleomycin-Induced Pulmonary Fibrosis by Regulating VEGF and Wnt Signaling.
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ABSTRACT:
SUBMITTER: Venkatadri R
PROVIDER: S-EPMC5662016 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
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MnTBAP Inhibits Bleomycin-Induced Pulmonary Fibrosis by Regulating VEGF and Wnt Signaling.
Venkatadri Rajkumar R Iyer Anand Krishnan V AK Ramesh Vani V Wright Clayton C Castro Carlos A CA Yakisich Juan S JS Azad Neelam N
Journal of cellular physiology 20160926 3
Cellular oxidative stress is implicated not only in lung injury but also in contributing to the development of pulmonary fibrosis. We demonstrate that a cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger, manganese (III) tetrakis (4-benzoic acid) porphyrin chloride (MnTBAP) significantly inhibited bleomycin-induced fibrogenic effects both in vitro and in vivo. Further investigation into the underlying mechanisms revealed that MnTBAP targets canonical Wnt and non-canoni ...[more]
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