Ontology highlight
ABSTRACT:
SUBMITTER: Gerstberger S
PROVIDER: S-EPMC5662206 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Gerstberger Stefanie S Meyer Cindy C Benjamin-Hong Sigi S Rodriguez Joe J Briskin Daniel D Bognanni Claudia C Bogardus Kimberly K Steller Hermann H Tuschl Thomas T
Cell reports 20171001 3
Non-coding RNA biogenesis in higher eukaryotes has not been fully characterized. Here, we studied the Drosophila melanogaster Rexo5 (CG8368) protein, a metazoan-specific member of the DEDDh 3'-5' single-stranded RNA exonucleases, by genetic, biochemical, and RNA-sequencing approaches. Rexo5 is required for small nucleolar RNA (snoRNA) and rRNA biogenesis and is essential in D. melanogaster. Loss-of-function mutants accumulate improperly 3' end-trimmed 28S rRNA, 5S rRNA, and snoRNA precursors in ...[more]