Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Y
PROVIDER: S-EPMC5662488 | biostudies-literature | 2017 Nov/Dec
REPOSITORIES: biostudies-literature
Zhou Yong Y Qin Shizhen S Hilton Tristan T Tang Li L Cruz Miguel M Hernandez Ruben R Moake Joel L JL Tian Qiang Q Frazier O H OH Dong Jing-Fei JF Nascimbene Angelo A
ASAIO journal (American Society for Artificial Internal Organs : 1992) 20171101 6
Patients supported by left ventricular assist devices (LVADs) often present with the loss of large von Willebrand factor (VWF) multimers. This VWF deficiency is believed to contribute to the bleeding diathesis of patients on LVAD support and is caused by excessive VWF cleavage by the metalloprotease ADAMTS-13 under high shear stress. However, only a small percentage of patients who have suffered the loss of large VWF multimers bleed. The actual rates of VWF cleavage in these patients have not be ...[more]