Ontology highlight
ABSTRACT:
SUBMITTER: Lima JB
PROVIDER: S-EPMC5662570 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Lima Jonilson Berlink JB Araújo-Santos Théo T Lázaro-Souza Milena M Carneiro Alan Brito AB Ibraim Izabela Coimbra IC Jesus-Santos Flávio Henrique FH Luz Nívea Farias NF Pontes Sara de Moura SM Entringer Petter Franco PF Descoteaux Albert A Bozza Patrícia Torres PT Soares Rodrigo Pedro RP Borges Valéria Matos VM
Scientific reports 20171030 1
Lipophosphoglycan (LPG) is a key virulence factor expressed on the surfaces of Leishmania promastigotes. Although LPG is known to activate macrophages, the underlying mechanisms resulting in the production of prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) via signaling pathways remain unknown. Here, the inflammatory response arising from stimulation by Leishmania infantum LPG and/or its lipid and glycan motifs was evaluated with regard to PGE<sub>2</sub> induction. Intact LPG, but not its glycan ...[more]