Ontology highlight
ABSTRACT:
SUBMITTER: Hoelper D
PROVIDER: S-EPMC5662737 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Hoelper Dominik D Huang Hongda H Jain Aayushi Y AY Patel Dinshaw J DJ Lewis Peter W PW
Nature communications 20171030 1
The ATRX-DAXX histone chaperone complex incorporates the histone variant H3.3 at heterochromatic regions in a replication-independent manner. Here, we present a high-resolution x-ray crystal structure of an interaction surface between ATRX and DAXX. We use single amino acid substitutions in DAXX that abrogate formation of the complex to explore ATRX-dependent and ATRX-independent functions of DAXX. We find that the repression of specific murine endogenous retroviruses is dependent on DAXX, but n ...[more]