Safety Outcomes After Thrombolysis for Acute Ischemic Stroke in Patients With Recent Stroke.

ABSTRACT:

Background and purpose

It is uncertain whether previous ischemic stroke within 3 months of receiving intravenous thrombolysis (tPA [tissue-type plasminogen activator]) for acute ischemic stroke (AIS) is associated with an increased risk of adverse outcomes.

Methods

Using administrative claims data, we identified adults with AIS who received intravenous tPA at California, New York, and Florida hospitals from 2005 to 2013. Our primary outcome was intracerebral hemorrhage, and our secondary outcomes were unfavorable discharge disposition and inpatient mortality. We used logistic regression to compare rates of outcomes in patients with and without previous ischemic stroke within 3 months of intravenous tPA for AIS.

Results

We identified 36 599 AIS patients treated with in

SUBMITTER: Merkler AE 

PROVIDER: S-EPMC5663184 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature