Ontology highlight
ABSTRACT:
SUBMITTER: Martinez L
PROVIDER: S-EPMC5663232 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Martinez Lorena L Arnaud Ophélie O Henin Emilie E Tao Houchao H Chaptal Vincent V Doshi Rupak R Andrieu Thibault T Dussurgey Sébastien S Tod Michel M Di Pietro Attilio A Zhang Qinghai Q Chang Geoffrey G Falson Pierre P
The FEBS journal 20140117 3
Human P-glycoprotein (P-gp) controls drugs bioavailability by pumping structurally unrelated drugs out of cells. The X-ray structure of the mouse P-gp ortholog has been solved, with two SSS enantiomers or one RRR enantiomer of the selenohexapeptide inhibitor QZ59, found within the putative drug-binding pocket (Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL et al. (2009). Science 323, 1718-1722). This offered the first opportunity to localize the ...[more]