Ontology highlight
ABSTRACT:
SUBMITTER: Liu N
PROVIDER: S-EPMC5663275 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Liu Nan N Niu Guoqing G Xie Zhoujie Z Chen Zhiyun Z Itzek Andreas A Kreth Jens J Gillaspy Allison A Zeng Lin L Burne Robert R Qi Fengxia F Merritt Justin J
Molecular cell 20150101 1
In both prokaryotes and eukaryotes, insight into gene function is typically obtained by in silico homology searches and/or phenotypic analyses of strains bearing mutations within open reading frames. However, the studies herein illustrate how mRNA function is not limited to the expression of a cognate protein. We demonstrate that a stress-induced protein-encoding mRNA (irvA) from the dental caries pathogen Streptococcus mutans directly modulates target mRNA (gbpC) stability through seed pairing ...[more]