Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury.
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ABSTRACT:
SUBMITTER: Cheng KT
PROVIDER: S-EPMC5663346 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
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Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury.
Cheng Kwong Tai KT Xiong Shiqin S Ye Zhiming Z Hong Zhigang Z Di Anke A Tsang Kit Man KM Gao Xiaopei X An Shejuan S Mittal Manish M Vogel Stephen M SM Miao Edward A EA Rehman Jalees J Malik Asrar B AB
The Journal of clinical investigation 20171009 11
Acute lung injury is a leading cause of death in bacterial sepsis due to the wholesale destruction of the lung endothelial barrier, which results in protein-rich lung edema, influx of proinflammatory leukocytes, and intractable hypoxemia. Pyroptosis is a form of programmed lytic cell death that is triggered by inflammatory caspases, but little is known about its role in EC death and acute lung injury. Here, we show that systemic exposure to the bacterial endotoxin lipopolysaccharide (LPS) causes ...[more]
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