Ontology highlight
ABSTRACT:
SUBMITTER: Rup B
PROVIDER: S-EPMC5663370 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Rup Bonita B Alon Sari S Amit-Cohen Bat-Chen BC Brill Almon Einat E Chertkoff Raul R Tekoah Yoram Y Rudd Pauline M PM
PloS one 20171031 10
Plants are a promising alternative for the production of biotherapeutics. Manufacturing in-planta adds plant specific glycans. To understand immunogenic potential of these glycans, we developed a validated method to detect plant specific glycan antibodies in human serum. Using this assay, low prevalence of pre-existing anti-plant glycan antibodies was found in healthy humans (13.5%) and in glucocerebrosidase-deficient Gaucher disease (GD) patients (5%). A low incidence (9% in naïve patient and n ...[more]