Ontology highlight
ABSTRACT:
SUBMITTER: Orellana-Tavra C
PROVIDER: S-EPMC5663390 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Orellana-Tavra Claudia C Haddad Salame S Marshall Ross J RJ Abánades Lázaro Isabel I Boix Gerard G Imaz Inhar I Maspoch Daniel D Forgan Ross S RS Fairen-Jimenez David D
ACS applied materials & interfaces 20171003 41
A critical bottleneck for the use of metal-organic frameworks (MOFs) as drug delivery systems has been allowing them to reach their intracellular targets without being degraded in the acidic environment of the lysosomes. Cells take up particles by endocytosis through multiple biochemical pathways, and the fate of these particles depends on these routes of entry. Here, we show the effect of functional group incorporation into a series of Zr-based MOFs on their endocytosis mechanisms, allowing us ...[more]