Ontology highlight
ABSTRACT:
SUBMITTER: O'Donnell C
PROVIDER: S-EPMC5663477 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
eLife 20171011
A leading theory holds that neurodevelopmental brain disorders arise from imbalances in excitatory and inhibitory (E/I) brain circuitry. However, it is unclear whether this one-dimensional model is rich enough to capture the multiple neural circuit alterations underlying brain disorders. Here, we combined computational simulations with analysis of in vivo two-photon Ca<sup>2+</sup> imaging data from somatosensory cortex of <i>Fmr1</i> knock-out (KO) mice, a model of Fragile-X Syndrome, to test t ...[more]