Glycolytic reprogramming through PCK2 regulates tumor initiation of prostate cancer cells.
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ABSTRACT:
SUBMITTER: Zhao J
PROVIDER: S-EPMC5663539 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
Glycolytic reprogramming through PCK2 regulates tumor initiation of prostate cancer cells.
Zhao Jiangsha J Li Jieran J Fan Teresa W M TWM Hou Steven X SX
Oncotarget 20170628 48
Tumor-initiating cells (TICs) play important roles in tumor progression and metastasis. Identifying the factors regulating TICs may open new avenues in cancer therapy. Here, we show that TIC-enriched prostate cancer cell clones use more glucose and secrete more lactate than TIC-low clones. We determined that elevated levels of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) are critical for the metabolic switch and the maintenance of TICs in prostate cancer. Information from prostate cancer p ...[more]
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