Ontology highlight
ABSTRACT:
SUBMITTER: Fabiani E
PROVIDER: S-EPMC5663578 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Fabiani Emiliano E Falconi Giulia G Noguera Nélida Inés NI Saulle Ernestina E Cicconi Laura L Divona Mariadomenica M Banella Cristina C Picardi Alessandra A Cerio Anna Maria AM Boe Letizia L Sanchez Massimo M Pelosi Elvira E Testa Ugo U Lo-Coco Francesco F Voso Maria Teresa MT
Oncotarget 20170920 48
Forkhead box (FOX) genes encode transcription factors, which regulate embryogenesis and play an important role in hematopoietic differentiation and in mesenchymal niche maintenance. Overexpression of the family member FOXC1 has been reported in solid tumors and acute myeloid leukemia (AML). We studied FOXC1 expression and function in acute promyelocytic leukemia (APL) and normal hematopoietic progenitors. FOXC1 mRNA and protein levels were significantly lower in primary marrow samples from 27 AP ...[more]