Ontology highlight
ABSTRACT:
SUBMITTER: Chen IC
PROVIDER: S-EPMC5663709 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Chen Ing-Chien IC Chiu Yi-Kai YK Yu Chung-Ming CM Lee Cheng-Chung CC Tung Chao-Ping CP Tsou Yueh-Liang YL Huang Yi-Jen YJ Lin Chia-Lung CL Chen Hong-Sen HS Wang Andrew H-J AH Yang An-Suei AS
Scientific reports 20171031 1
Pandemic and epidemic outbreaks of influenza A virus (IAV) infection pose severe challenges to human society. Passive immunotherapy with recombinant neutralizing antibodies can potentially mitigate the threats of IAV infection. With a high throughput neutralizing antibody discovery platform, we produced artificial anti-hemagglutinin (HA) IAV-neutralizing IgGs from phage-displayed synthetic scFv libraries without necessitating prior memory of antibody-antigen interactions or relying on affinity m ...[more]