Ontology highlight
ABSTRACT:
SUBMITTER: Johnson RE
PROVIDER: S-EPMC5663853 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Johnson Robert E RE Tien Nai-Wen NW Shen Ning N Pearson James T JT Soto Florentina F Kerschensteiner Daniel D
Nature communications 20171031 1
Vision in dim light depends on synapses between rods and rod bipolar cells (RBCs). Here, we find that these synapses exist in multiple configurations, in which single release sites of rods are apposed by one to three postsynaptic densities (PSDs). Single RBCs often form multiple PSDs with one rod; and neighboring RBCs share ~13% of their inputs. Rod-RBC synapses develop while ~7% of RBCs undergo programmed cell death (PCD). Although PCD is common throughout the nervous system, its influences on ...[more]