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Head-to-Head Comparison of 68Ga-Citrate and 18F-FDG PET/CT for Detection of Infectious Foci in Patients with Staphylococcus aureus Bacteraemia.


ABSTRACT: This study evaluated the potential of 68Ga-citrate positron emission tomography/computed tomography (PET/CT) for the detection of infectious foci in patients with Staphylococcus aureus bacteraemia by comparing it with 2-[18F]fluoro-2-deoxy-D-glucose (18F-FDG) PET/CT.Four patients admitted to hospital due to S. aureus bacteraemia underwent both 18F-FDG and 68Ga-citrate whole-body PET/CT scans to detect infectious foci.The time from hospital admission and the initiation of antibiotic treatment to the first PET/CT was 4-10 days. The time interval between 18F-FDG and 68Ga-citrate PET/CT was 1-4 days. Three patients had vertebral osteomyelitis (spondylodiscitis) and one had osteomyelitis in the toe; these were detected by both 18F-FDG (maximum standardised uptake value [SUVmax] 6.0 ± 1.0) and 68Ga-citrate (SUVmax??6.8 ± 3.5, P = 0.61). Three patients had soft tissue infectious foci, with more intense 18F-FDG uptake (SUVmax??6.5 ± 2.5) than 68Ga-citrate uptake (SUVmax??3.9 ± 1.2, P = 0.0033).Our small cohort of patients with S. aureus bacteraemia revealed that 68Ga-citrate PET/CT is comparable to 18F-FDG PET/CT for detection of osteomyelitis, whereas 18F-FDG resulted in a higher signal for the detection of soft tissue infectious foci.

SUBMITTER: Salomaki SP 

PROVIDER: S-EPMC5664237 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Head-to-Head Comparison of <sup>68</sup>Ga-Citrate and <sup>18</sup>F-FDG PET/CT for Detection of Infectious Foci in Patients with <i>Staphylococcus aureus</i> Bacteraemia.

Salomäki Soile P SP   Kemppainen Jukka J   Hohenthal Ulla U   Luoto Pauliina P   Eskola Olli O   Nuutila Pirjo P   Seppänen Marko M   Pirilä Laura L   Oksi Jarmo J   Roivainen Anne A  

Contrast media & molecular imaging 20171017


<h4>Purpose</h4>This study evaluated the potential of <sup>68</sup>Ga-citrate positron emission tomography/computed tomography (PET/CT) for the detection of infectious foci in patients with <i>Staphylococcus aureus</i> bacteraemia by comparing it with 2-[<sup>18</sup>F]fluoro-2-deoxy-<i>D</i>-glucose (<sup>18</sup>F-FDG) PET/CT.<h4>Methods</h4>Four patients admitted to hospital due to <i>S. aureus</i> bacteraemia underwent both <sup>18</sup>F-FDG and <sup>68</sup>Ga-citrate whole-body PET/CT sca  ...[more]

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