Ontology highlight
ABSTRACT:
SUBMITTER: Gilardin L
PROVIDER: S-EPMC5664387 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Gilardin Laurent L Delignat Sandrine S Peyron Ivan I Ing Mathieu M Lone Yu-Chun YC Gangadharan Bagirath B Michard Baptiste B Kherabi Yousra Y Sharma Meenu M Pashov Anastas A Latouche Jean-Baptiste JB Hamieh Mohamad M Toutirais Olivier O Loiseau Pascale P Galicier Lionel L Veyradier Agnès A Kaveri Srini S Maillère Bernard B Coppo Paul P Lacroix-Desmazes Sébastien S
Haematologica 20170727 11
Acquired thrombotic thrombocytopenic purpura is a rare and severe disease characterized by auto-antibodies directed against "A Disintegrin And Metalloproteinase with Thrombospondin type 1 repeats, 13<sup>th</sup> member" (ADAMTS13), a plasma protein involved in hemostasis. Involvement of CD4<sup>+</sup> T cells in the pathogenesis of the disease is suggested by the IgG isotype of the antibodies. However, the nature of the CD4<sup>+</sup> T-cell epitopes remains poorly characterized. Here, we det ...[more]