Ontology highlight
ABSTRACT:
SUBMITTER: Stewart K
PROVIDER: S-EPMC5664512 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Stewart Katherine K Tang You Chi YC Shafer Maxwell E R MER Graham-Paquin Adda-Lee AL Bouchard Maxime M
Proceedings of the National Academy of Sciences of the United States of America 20171009 43
The elimination of unwanted cells by apoptosis is necessary for tissue morphogenesis. However, the cellular control of morphogenetic apoptosis is poorly understood, notably the modulation of cell sensitivity to apoptotic stimuli. Ureter maturation, the process by which the ureter is displaced to the bladder wall, represents an exquisite example of morphogenetic apoptosis, requiring the receptor protein tyrosine phosphatases (RPTPs): LAR and RPTPσ. Here we show that LAR-RPTPs act through cellular ...[more]