Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen LP
PROVIDER: S-EPMC5664525 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Nguyen Long P LP Al-Sawalha Nour A NA Parra Sergio S Pokkunuri Indira I Omoluabi Ozozoma O Okulate Adedoyin A AA Windham Li Elizabeth E Hazen Matthew M Gonzalez-Granado Jose M JM Daly Craig J CJ McGrath John C JC Tuvim Michael J MJ Knoll Brian J BJ Dickey Burton F BF Bond Richard A RA
Proceedings of the National Academy of Sciences of the United States of America 20171009 43
The mostly widely used bronchodilators in asthma therapy are β<sub>2</sub>-adrenoreceptor (β<sub>2</sub>AR) agonists, but their chronic use causes paradoxical adverse effects. We have previously determined that β<sub>2</sub>AR activation is required for expression of the asthma phenotype in mice, but the cell types involved are unknown. We now demonstrate that β<sub>2</sub>AR signaling in the airway epithelium is sufficient to mediate key features of the asthmatic responses to IL-13 in murine mo ...[more]