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ABSTRACT: Background
There is considerable evidence of the favourable role of more physical activity (PA) in fighting against dementia. However, the shape of the dose-response relationship is still unclear.Objective
To quantitatively investigate the relationship between dementia and PA.Design
PubMed, EMBASE, Ovid and the Cochrane Library were searched for prospective studies published from 1 January 1995 to 15 October 2016. Two types of meta-analyses were performed with a focus on the dose-response relationship using two stage generalised least squares regression.Results
The primary analysis exhibited a dose-response trend for all-cause dementia (ACD), Alzheimer's disease (AD) but not for vascular dementia (VD). In the dose-response analysis, either ACD (ptrend <0.005; pnon-linearity=0.87) or AD (p trend <0.005; pnon-linearity=0.10) exhibited a linear relationship with leisure time PA (LTPA) over the observed range (0-2000 kcal/week or 0-45 metabolic equivalent of task hours per week (MET-h/week)). Specifically, for every 500 kcal or 10 MET-h increase per week, there was, on average, 10% and 13% decrease in the risk of ACD and AD, respectively.Conclusions
We have reported, for the first time, the dose-response relationship between LTPA and dementia, further supporting the international PA guideline from the standpoint of dementia prevention.
SUBMITTER: Xu W
PROVIDER: S-EPMC5665289 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Xu Wei W Wang Hui Fu HF Wan Yu Y Tan Chen-Chen CC Yu Jin-Tai JT Yu Jin-Tai JT Tan Lan L
BMJ open 20171022 10
<h4>Background</h4>There is considerable evidence of the favourable role of more physical activity (PA) in fighting against dementia. However, the shape of the dose-response relationship is still unclear.<h4>Objective</h4>To quantitatively investigate the relationship between dementia and PA.<h4>Design</h4>PubMed, EMBASE, Ovid and the Cochrane Library were searched for prospective studies published from 1 January 1995 to 15 October 2016. Two types of meta-analyses were performed with a focus on ...[more]