Ontology highlight
ABSTRACT:
SUBMITTER: Hill JT
PROVIDER: S-EPMC5665485 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Hill Jonathon T JT Demarest Bradley B Gorsi Bushra B Smith Megan M Yost H Joseph HJ
Development (Cambridge, England) 20170814 19
During embryogenesis the heart forms as a linear tube that then undergoes multiple simultaneous morphogenetic events to obtain its mature shape. To understand the gene regulatory networks (GRNs) driving this phase of heart development, during which many congenital heart disease malformations likely arise, we conducted an RNA-seq timecourse in zebrafish from 30 hpf to 72 hpf and identified 5861 genes with altered expression. We clustered the genes by temporal expression pattern, identified transc ...[more]