Dataset Information

Progression of Parkinson's disease is associated with gut dysbiosis: Two-year follow-up study.

ABSTRACT: We previously reported gut dysbiosis in patients with Parkinson's disease (PD).The aim of this study is to examine whether gut dysbiosis correlates with the progression of PD.We examined changes in gut microbiota and demographic features in 2 years in 36 PD patients.A change of total UPDRS scores in 2 years was predicted by the counts of Bifidobacterium and Atopobium cluster at year 0 with a correlation coefficient of 0.52. Correlation analysis additionally revealed that low counts of Bifidobacterium and Bacteroides fragilis at year 0 were associated with worsening of UPDRS I scores in 2 years. In addition, low counts of Bifidobacterium at year 0 were associated with worsening of hallucinations/delusions in 2 years. Similarly, low counts of B. fragilis at year 0 were associated with worsening of motivation/initiative in 2 years. The patients were evenly divided into the deteriorated and stable groups based on the degree of worsening of total UPDRS scores. The deteriorated group had lower counts of Bifidobacterium, B. fragilis, and Clostridium leptium than the stable group at year 0 but not at year 2, suggesting that the deteriorated group may demonstrate accelerated lowering of these bacteria at year 0.The total counts of intestinal bacterial decrease in the course of PD progression. Temporal profiles of lowering of bacterial counts are likely to be different from bacteria to bacteria, and also between the deteriorating and stable groups, which may be able to be exploited to differentiate patients with rapidly and slowly progressive PD pathology.

SUBMITTER: Minato T

PROVIDER: S-EPMC5665539 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Progression of Parkinson's disease is associated with gut dysbiosis: Two-year follow-up study.

Minato Tomomi T Maeda Tetsuya T Fujisawa Yoshiro Y Tsuji Hirokazu H Nomoto Koji K Ohno Kinji K Hirayama Masaaki M

PloS one 20171101 11

<h4>Background</h4>We previously reported gut dysbiosis in patients with Parkinson's disease (PD).<h4>Objective</h4>The aim of this study is to examine whether gut dysbiosis correlates with the progression of PD.<h4>Methods</h4>We examined changes in gut microbiota and demographic features in 2 years in 36 PD patients.<h4>Results</h4>A change of total UPDRS scores in 2 years was predicted by the counts of Bifidobacterium and Atopobium cluster at year 0 with a correlation coefficient of 0.52. Cor ...[more]

PMID: 29091972

Similar Datasets

Project description:ObjectivesTo investigate both cross-sectional and time-related changes of striatal and whole-brain microstructural properties in different stages of Huntington's disease (HD) using diffusion tensor imaging.Experimental designFrom the TRACK-HD study, premanifest gene carriers (preHD), early manifest HD and controls were scanned at baseline and 2-year follow-up. Stratification of the preHD group into a far (preHD-A) and near (preHD-B) to predicted disease onset was performed. Age-corrected histograms of whole-brain white matter (WM), gray matter (GM) and striatal diffusion measures were computed and normalised by the number of voxels in each subject's data set.Principle observationsHigher cross-sectional mean, axial and radial diffusivities were found in both WM (P ? 0.001) and GM (P ? 0.001) of the manifest HD compared to the preHD and control groups. In preHD, only WM axial diffusivity (AD) was higher than in controls (P ? 0.01). This finding remained valid only in preHD-B (P ? 0.001). AD was also higher in the striatum of preHD-B compared to controls and preHD-A (P ? 0.01). Fractional anisotropy (FA) lacked sensitivity in differentiating between the groups. Histogram peak heights were generally lower in manifest HD compared to the preHD and control groups. No longitudinal differences were found in the degree of diffusivity change between the groups in the two year follow-up. There was a significant relationship between diffusivity and neurocognitive measures.ConclusionsAlterations in cross-sectional diffusion profiles between manifest HD subjects and controls were evident, both in whole-brain and striatum. In the preHD stage, only AD alterations were found, a finding suggesting that this metric is a sensitive marker for early change in HD prior to disease manifestation. The individual diffusivities were superior to FA in revealing pathologic microstructural brain alterations. Diffusion measures were well related to clinical functioning and disease stage.

Dataset Information

Progression of Parkinson's disease is associated with gut dysbiosis: Two-year follow-up study.

Publications

Progression of Parkinson's disease is associated with gut dysbiosis: Two-year follow-up study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets