Ontology highlight
ABSTRACT:
SUBMITTER: Mager LF
PROVIDER: S-EPMC5665647 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Mager Lukas Franz LF Koelzer Viktor Hendrik VH Stuber Regula R Thoo Lester L Keller Irene I Koeck Ivonne I Langenegger Maya M Simillion Cedric C Pfister Simona P SP Faderl Martin M Genitsch Vera V Tcymbarevich Irina I Juillerat Pascal P Li Xiaohong X Xia Yu Y Karamitopoulou Eva E Lyck Ruth R Zlobec Inti I Hapfelmeier Siegfried S Bruggmann Rémy R Bruggmann Rémy R McCoy Kathy D KD Macpherson Andrew J AJ Müller Christoph C Beutler Bruce B Krebs Philippe P
eLife 20171004
Aberrant alternative pre-mRNA splicing (AS) events have been associated with several disorders. However, it is unclear whether deregulated AS directly contributes to disease. Here, we reveal a critical role of the AS regulator epithelial splicing regulator protein 1 (ESRP1) for intestinal homeostasis and pathogenesis. In mice, reduced ESRP1 function leads to impaired intestinal barrier integrity, increased susceptibility to colitis and altered colorectal cancer (CRC) development. Mechanistically ...[more]