Pittsburgh compound-B PET white matter imaging and cognitive function in late multiple sclerosis.

ABSTRACT: BACKGROUND:There is growing interest in white matter (WM) imaging with positron emission tomography (PET). OBJECTIVES:We studied the association of cognitive function in late multiple sclerosis (MS) with cortical and WM Pittsburgh compound-B PET (PiB-PET) binding. METHODS:In the population-based Mayo Clinic Study of Aging, 24 of 4869 participants had MS (12 underwent PiB-PET). Controls were age and sex matched (5:1). We used automated or semi-automated processing for quantitative image analyses and conditional logistic regression for group differences. RESULTS:MS patients had lower memory ( p?=?0.03) and language ( p?=?0.02) performance; smaller thalamic volumes ( p?=?0.003); and thinner temporal ( p?=?0.001) and frontal ( p?=?0.045) cortices on magnetic resonance imaging (MRI) than controls. There was no difference in global cortical PiB standardized uptake value ratios between MS and controls ( p?=?0.35). PiB uptake was lower in areas of WM hyperintensities compared to normal-appearing white matter (NAWM) in MS ( p?=?0.0002). Reduced PiB uptake in both the areas of WM hyperintensities ( r?=?0.65; p?=?0.02) and NAWM ( r?=?0.69; p?=?0.01) was associated with decreased visuospatial performance in MS. CONCLUSION:PiB uptake in the cortex in late MS is not different from normal age-matched controls. PiB uptake in the WM in late MS may be a marker of the large network structures' integrity such as those involved in visuospatial performance.

SUBMITTER: Zeydan B 

PROVIDER: S-EPMC5665724 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature