Casposons: mobile genetic elements that gave rise to the CRISPR-Cas adaptation machinery.
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ABSTRACT:
SUBMITTER: Krupovic M
PROVIDER: S-EPMC5665730 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Publications
Casposons: mobile genetic elements that gave rise to the CRISPR-Cas adaptation machinery.
Krupovic Mart M Béguin Pierre P Koonin Eugene V EV
Current opinion in microbiology 20170501
A casposon, a member of a distinct superfamily of archaeal and bacterial self-synthesizing transposons that employ a recombinase (casposase) homologous to the Cas1 endonuclease, appears to have given rise to the adaptation module of CRISPR-Cas systems as well as the CRISPR repeats themselves. Comparison of the mechanistic features of the reactions catalyzed by the casposase and the Cas1-Cas2 heterohexamer, the CRISPR integrase, reveals close similarity but also important differences that explain ...[more]
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