Ontology highlight
ABSTRACT:
SUBMITTER: Zapadka KL
PROVIDER: S-EPMC5665799 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Zapadka Karolina L KL Becher Frederik J FJ Gomes Dos Santos A L AL Jackson Sophie E SE
Interface focus 20171020 6
The number of biological therapeutic agents in the clinic and development pipeline has increased dramatically over the last decade and the number will undoubtedly continue to increase in the coming years. Despite this fact, there are considerable challenges in the development, production and formulation of such biologics particularly with respect to their physical stabilities. There are many cases where self-association to form either amorphous aggregates or highly structured fibrillar species l ...[more]