Ontology highlight
ABSTRACT:
SUBMITTER: Mitsuhashi S
PROVIDER: S-EPMC5665936 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Mitsuhashi Satomi S Nakagawa So S Takahashi Ueda Mahoko M Imanishi Tadashi T Frith Martin C MC Mitsuhashi Hiroaki H
Scientific reports 20171101 1
Subtelomeric macrosatellite repeats are difficult to sequence using conventional sequencing methods owing to the high similarity among repeat units and high GC content. Sequencing these repetitive regions is challenging, even with recent improvements in sequencing technologies. Among these repeats, a haplotype carrying a particular sequence and shortening of the D4Z4 array on human chromosome 4q35 causes one of the most prevalent forms of muscular dystrophy with autosomal-dominant inheritance, f ...[more]