Combating virulence of Gram-negative bacilli by OmpA inhibition.
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ABSTRACT:
SUBMITTER: Vila-Farres X
PROVIDER: S-EPMC5666006 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
Combating virulence of Gram-negative bacilli by OmpA inhibition.
Vila-Farrés Xavier X Parra-Millán Raquel R Sánchez-Encinales Viviana V Varese Monica M Ayerbe-Algaba Rafael R Bayó Nuria N Guardiola Salvador S Pachón-Ibáñez María Eugenia ME Kotev Martin M García Jesús J Teixidó Meritxell M Vila Jordi J Pachón Jerónimo J Giralt Ernest E Smani Younes Y
Scientific reports 20171031 1
Preventing the adhesion of pathogens to host cells provides an innovative approach to tackling multidrug-resistant bacteria. In this regard, the identification of outer membrane protein A (OmpA) as a key bacterial virulence factor has been a major breakthrough. The use of virtual screening helped us to identify a cyclic hexapeptide AOA-2 that inhibits the adhesion of Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia coli to host cells and the formation of biofilm, thereby preventin ...[more]
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