Ontology highlight
ABSTRACT:
SUBMITTER: Tanaka H
PROVIDER: S-EPMC5666028 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Tanaka Hironori H Hazama Shoichi S Iida Michihisa M Tsunedomi Ryouichi R Takenouchi Hiroko H Nakajima Masao M Tokumitsu Yukio Y Kanekiyo Shinsuke S Shindo Yoshitaro Y Tomochika Shinobu S Tokuhisa Yoshihiro Y Sakamoto Kazuhiko K Suzuki Nobuaki N Takeda Shigeru S Yamamoto Shigeru S Yoshino Shigefumi S Ueno Tomio T Hamamoto Yoshihiko Y Fujita Yusuke Y Tanaka Hiroaki H Tahara Ko K Shimizu Ryoichi R Okuno Kiyotaka K Fujita Koji K Kuroda Masahiko M Nakamura Yusuke Y Nagano Hiroaki H
Cancer science 20170922 11
Many clinical trials of peptide vaccines have been conducted. However, these vaccines have provided clinical benefits in only a small fraction of patients. The purpose of the present study was to explore microRNAs (miRNAs) as novel predictive biomarkers for the efficacy of vaccine treatment against colorectal cancer. First, we carried out microarray analysis of pretreatment cancer tissues in a phase I study, in which peptide vaccines alone were given. Candidate miRNAs were selected by comparison ...[more]