Ontology highlight
ABSTRACT:
SUBMITTER: Fumery M
PROVIDER: S-EPMC5666307 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Fumery Mathurin M Speca Silvia S Langlois Audrey A Davila Anne-Marie AM Dubuquoy Caroline C Grauso Marta M Martin Mena Anthony A Figeac Martin M Metzger Daniel D Rousseaux Christel C Colombel Jean-Frederic JF Dubuquoy Laurent L Desreumaux Pierre P Bertin Benjamin B
EMBO molecular medicine 20171101 11
Lactase (LCT) deficiency affects approximately 75% of the world's adult population and may lead to lactose malabsorption and intolerance. Currently, the regulation of LCT gene expression remains poorly known. Peroxisome proliferator activator receptorγ (PPARγ) is a key player in carbohydrate metabolism. While the intestine is essential for carbohydrate digestion and absorption, the role of PPARγ in enterocyte metabolic functions has been poorly investigated. This study aims at characterizing PPA ...[more]