Ontology highlight
ABSTRACT:
SUBMITTER: Oak P
PROVIDER: S-EPMC5666314 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
EMBO molecular medicine 20171101 11
Neonatal chronic lung disease (nCLD) affects a significant number of neonates receiving mechanical ventilation with oxygen-rich gas (MV-O<sub>2</sub>). Regardless, the primary molecular driver of the disease remains elusive. We discover significant enrichment for SNPs in the PDGF-Rα gene in preterms with nCLD and directly test the effect of PDGF-Rα haploinsufficiency on the development of nCLD using a preclinical mouse model of MV-O<sub>2</sub> In the context of MV-O<sub>2</sub>, attenuated PDGF ...[more]