Abrin Toxicity and Bioavailability after Temperature and pH Treatment.
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ABSTRACT:
SUBMITTER: Tam CC
PROVIDER: S-EPMC5666367 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
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Abrin Toxicity and Bioavailability after Temperature and pH Treatment.
Tam Christina C CC Henderson Thomas D TD Stanker Larry H LH He Xiaohua X Cheng Luisa W LW
Toxins 20171013 10
Abrin, one of most potent toxins known to man, is derived from the rosary pea (jequirity pea), <i>Abrus precatorius</i> and is a potential bioterror weapon. The temperature and pH stability of abrin was evaluated with an in vitro cell free translation (CFT) assay, a Vero cell culture cytotoxicity assay, and an in vivo mouse bioassay. pH treatment of abrin had no detrimental effect on its stability and toxicity as seen either in vitro or in vivo. Abrin exposure to increasing temperatures did not ...[more]
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