Ontology highlight
ABSTRACT:
SUBMITTER: Venkat S
PROVIDER: S-EPMC5666399 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
FEBS open bio 20171016 11
Reversible lysine acetylation is one of the most widely distributed post-translational modifications; it is involved in a variety of biological processes and can be found in all three domains of life. Acetyltransferases and deacetylases work coordinately to control levels of protein acetylation. In this work, we applied the genetic code expansion strategy to site-specifically incorporate <i>N</i><sup>ε</sup>-thioacetyl-l-lysine (TAcK) as an analog of <i>N</i><sup>ε</sup>-acetyl-l-lysine (AcK) in ...[more]