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Plasmid-mediated mcr-1 in carbapenem-susceptible Escherichia coli ST156 causing a blood infection: an unnoticeable spread of colistin resistance in Brazil?


ABSTRACT: We describe an IncX4 pHC891/16mcr plasmid carrying mcr-1 in a colistin-resistant and carbapenem-susceptible E. coli isolate (HC891/16), ST156, which caused a blood infection in a Brazilian patient with gallbladder adenocarcinoma.Strain HC891/16 was subjected to whole genome sequencing using the MiSeq Platform (Illumina, Inc., USA). Assembly was performed using Mira and ABACAS.The isolates showed resistance only to ciprofloxacin, ampicillin and cefoxitin, and whole-genome sequencing revealed the presence of aac(6')Ib-cr and blaTEM1.Our findings warn of the possible silent dissemination of colistin resistance by carbapenem-susceptible mcr-1 producers, as colistin susceptibility is commonly tested only among carbapenem-resistant isolates.

SUBMITTER: Rossi F 

PROVIDER: S-EPMC5666441 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Plasmid-mediated mcr-1 in carbapenem-susceptible Escherichia coli ST156 causing a blood infection: an unnoticeable spread of colistin resistance in Brazil?

Rossi Flavia F   Girardello Raquel R   Morais Carlos C   Cury Ana Paula AP   Martins Layla Farage LF   da Silva Aline Maria AM   Abdala Edson E   Setubal João Carlos JC   da Silva Duarte Alberto José AJ  

Clinics (Sao Paulo, Brazil) 20171001 10


<h4>Objective</h4>We describe an IncX4 pHC891/16mcr plasmid carrying mcr-1 in a colistin-resistant and carbapenem-susceptible E. coli isolate (HC891/16), ST156, which caused a blood infection in a Brazilian patient with gallbladder adenocarcinoma.<h4>Methods</h4>Strain HC891/16 was subjected to whole genome sequencing using the MiSeq Platform (Illumina, Inc., USA). Assembly was performed using Mira and ABACAS.<h4>Results</h4>The isolates showed resistance only to ciprofloxacin, ampicillin and ce  ...[more]

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