Asymmetry in Signal Oscillations Contributes to Efficiency of Periodic Systems.

ABSTRACT: Oscillations are an important feature of cellular signaling that result from complex combinations of positive- and negative-feedback loops. The encoding and decoding mechanisms of oscillations based on amplitude and frequency have been extensively discussed in the literature in the context of intercellular and intracellular signaling. However, the fundamental questions of whether and how oscillatory signals offer any competitive advantages-and, if so, what-have not been fully answered. We investigated established oscillatory mechanisms and designed a study to analyze the oscillatory characteristics of signaling molecules and system output in an effort to answer these questions. Two classic oscillators, Goodwin and PER, were selected as the model systems, and corresponding no-feedback model

SUBMITTER: Bae SA 

PROVIDER: S-EPMC5666575 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature