Test-Retest Variability in Lesion SUV and Lesion SUR in ¹⁸F-FDG PET: An Analysis of Data from Two Prospective Multicenter Trials.

ABSTRACT: Quantitative assessment of radio- and chemotherapy response with ¹⁸F-FDG whole-body PET has attracted increasing interest in recent years. In most published work, SUV has been used for this purpose. In the context of therapy response assessment, the reliability of lesion SUVs, notably their test-retest stability, thus becomes crucial. However, a recent study demonstrated substantial test-retest variability (TRV) in SUVs. The purpose of the present study was to investigate whether the tumor-to-blood SUV ratio (SUR) can improve TRV in tracer uptake. Methods: 73 patients with advanced non-small cell lung cancer from the prospective multicenter trials ACRIN 6678 (n = 34) and MK-0646-008 (n = 39) were included in this study. All patients underwent two ¹⁸

SUBMITTER: Hofheinz F 

PROVIDER: S-EPMC5666644 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature