Ontology highlight
ABSTRACT:
SUBMITTER: Zhou H
PROVIDER: S-EPMC5666675 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Zhou Huanyu H Morales Maria Gabriela MG Hashimoto Hisayuki H Dickson Matthew E ME Song Kunhua K Ye Wenduo W Kim Min S MS Niederstrasser Hanspeter H Wang Zhaoning Z Chen Beibei B Posner Bruce A BA Bassel-Duby Rhonda R Olson Eric N EN
Genes & development 20170901 17
Direct reprogramming of fibroblasts to cardiomyocytes represents a potential means of restoring cardiac function following myocardial injury. AKT1 in the presence of four cardiogenic transcription factors, GATA4, HAND2, MEF2C, and TBX5 (AGHMT), efficiently induces the cardiac gene program in mouse embryonic fibroblasts but not adult fibroblasts. To identify additional regulators of adult cardiac reprogramming, we performed an unbiased screen of transcription factors and cytokines for those that ...[more]