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The Diagnostic, Prognostic, and Therapeutic Utility of Molecular Testing in a Patient with Waldenstrom's Macroglobulinemia.

ABSTRACT: The application of molecular genomics and our understanding of its clinical implications in the diagnosis, prognostication and treatment of lymphoproliferative disorders has rapidly evolved over the past few years. Of particular importance are indolent B-cell malignancies where tumour cell survival and proliferation are commonly driven by mutations involving the B-cell receptor and downstream signalling pathways. In addition, the increasing number of novel therapies and targeted agents have provided clinicians with new therapeutic options with the aim of exploiting such mutations. In this case report, we highlight one such success story involving the diagnostic impact of the MYD88L265P mutation in Waldenstrom's macroglobulinemia (WM), its prognostic implications and effect on choice of therapy in the era of novel therapies.

SUBMITTER: Chin CK

PROVIDER: S-EPMC5666720 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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The Diagnostic, Prognostic, and Therapeutic Utility of Molecular Testing in a Patient with Waldenstrom's Macroglobulinemia.

Chin Collin K CK Leslie Connull C Grove Carolyn S CS Van Vliet Chris C Cheah Chan Yoon CY

International journal of molecular sciences 20170922 10

The application of molecular genomics and our understanding of its clinical implications in the diagnosis, prognostication and treatment of lymphoproliferative disorders has rapidly evolved over the past few years. Of particular importance are indolent B-cell malignancies where tumour cell survival and proliferation are commonly driven by mutations involving the B-cell receptor and downstream signalling pathways. In addition, the increasing number of novel therapies and targeted agents have prov ...[more]

PMID: 28937595

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Prognostic factors and indications for treatment of Waldenstrom's Macroglobulinemia.

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Waldenstrom's macroglobulinemia front line treatment.

Project description: Not available

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Genomic landscape of Waldenstrom's macroglobulinemia.

Project description: Not available

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Patient preferences regarding treatment options for Waldenstrom's macroglobulinemia: A discrete choice experiment.

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Managing Waldenstrom's macroglobulinemia with BTK inhibitors.

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Monoclonal antibody-based therapies for Waldenstrom's macroglobulinemia

Project description:Highlights • anti-CD20 monoclonal antibodies have revolutionized treatment in WM.• Rituximab is the backbone of WM treatment in combination with chemotherapy and/or PIs.• Newer monoclonal antibodies, targeting CD20 or other surface antigens are emerging.• Small molecule based therapy, such as BTK or bcl-2 inhibitors are also gaining ground.• MoAbs-based combinations are an active, fixed duration, safe and cost effective option. Monoclonal antibodies have established an important role in the treatment armamentarium of hematological malignancies, including Waldenström's macroglobulinemia. Rituximab, an anti-CD20 monoclonal antibody, is established as standard therapy for this unique low grade lymphoma, due to its effectiveness and safety as monotherapy, in combination with chemotherapy or other targeted therapies in WM. Newer monoclonal antibodies, targeting CD20 or other surface antigens, have shown to be effective in patients with WM. In the current review we attempt to provide an overview of the mechanisms of action of monoclonal antibodies and discuss clinical evidence that support their use in WM and their therapeutic potential.

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