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Synthesis and In Vitro Characterization of Fe3+-Doped Layered Double Hydroxide Nanorings as a Potential Imageable Drug Delivery System.

ABSTRACT: Highly dispersed Fe3+-doped layered double hydroxide (LDH-Fe) nanorings were obtained by a simple coprecipitation-acid etching approach. The morphology, structure, magnetic resonance imaging (MRI) performance in vitro, drug loading and releasing, Fe3+ leakage, and cytotoxicity of the as-prepared LDH-Fe nanorings were characterized. The LDH-Fe nanorings showed good water dispersity and a well-crystallized structure. The DLS average size of nanoparticles was measured to be 94.5 nm. Moreover, the MRI tests showed a favourable T?-weighted MRI performance of the LDH-Fe nanoring with r? values of 0.54 and 1.68, and low r?/r? ratios of 10.1 and 6.3, pre- and after calcination, respectively. The nanoparticles also showed high model drug (ibuprofen) loading capacities, low Fe3+ leakage, and negligible cytotoxicity. All these results demonstrate the potential of LDH-Fe nanorings as an imageable drug delivery system.

SUBMITTER: Wang L 

PROVIDER: S-EPMC5666946 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Synthesis and In Vitro Characterization of Fe<sup>3+</sup>-Doped Layered Double Hydroxide Nanorings as a Potential Imageable Drug Delivery System.

Wang Lijun L   Wang Yusen Y   Wang Xiaoxia X  

Materials (Basel, Switzerland) 20170927 10

Highly dispersed Fe<sup>3+</sup>-doped layered double hydroxide (LDH-Fe) nanorings were obtained by a simple coprecipitation-acid etching approach. The morphology, structure, magnetic resonance imaging (MRI) performance in vitro, drug loading and releasing, Fe<sup>3+</sup> leakage, and cytotoxicity of the as-prepared LDH-Fe nanorings were characterized. The LDH-Fe nanorings showed good water dispersity and a well-crystallized structure. The DLS average size of nanoparticles was measured to be 94  ...[more]

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