Dataset Information

Multi-categorical deep learning neural network to classify retinal images: A pilot study employing small database.

ABSTRACT: Deep learning emerges as a powerful tool for analyzing medical images. Retinal disease detection by using computer-aided diagnosis from fundus image has emerged as a new method. We applied deep learning convolutional neural network by using MatConvNet for an automated detection of multiple retinal diseases with fundus photographs involved in STructured Analysis of the REtina (STARE) database. Dataset was built by expanding data on 10 categories, including normal retina and nine retinal diseases. The optimal outcomes were acquired by using a random forest transfer learning based on VGG-19 architecture. The classification results depended greatly on the number of categories. As the number of categories increased, the performance of deep learning models was diminished. When all 10 categories were included, we obtained results with an accuracy of 30.5%, relative classifier information (RCI) of 0.052, and Cohen's kappa of 0.224. Considering three integrated normal, background diabetic retinopathy, and dry age-related macular degeneration, the multi-categorical classifier showed accuracy of 72.8%, 0.283 RCI, and 0.577 kappa. In addition, several ensemble classifiers enhanced the multi-categorical classification performance. The transfer learning incorporated with ensemble classifier of clustering and voting approach presented the best performance with accuracy of 36.7%, 0.053 RCI, and 0.225 kappa in the 10 retinal diseases classification problem. First, due to the small size of datasets, the deep learning techniques in this study were ineffective to be applied in clinics where numerous patients suffering from various types of retinal disorders visit for diagnosis and treatment. Second, we found that the transfer learning incorporated with ensemble classifiers can improve the classification performance in order to detect multi-categorical retinal diseases. Further studies should confirm the effectiveness of algorithms with large datasets obtained from hospitals.

SUBMITTER: Choi JY

PROVIDER: S-EPMC5667846 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Multi-categorical deep learning neural network to classify retinal images: A pilot study employing small database.

Choi Joon Yul JY Yoo Tae Keun TK Seo Jeong Gi JG Kwak Jiyong J Um Terry Taewoong TT Rim Tyler Hyungtaek TH

PloS one 20171102 11

Deep learning emerges as a powerful tool for analyzing medical images. Retinal disease detection by using computer-aided diagnosis from fundus image has emerged as a new method. We applied deep learning convolutional neural network by using MatConvNet for an automated detection of multiple retinal diseases with fundus photographs involved in STructured Analysis of the REtina (STARE) database. Dataset was built by expanding data on 10 categories, including normal retina and nine retinal diseases. ...[more]

PMID: 29095872

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Project description:Coronavirus (COVID-19) was first observed in Wuhan, China, and quickly propagated worldwide. It is considered the supreme crisis of the present era and one of the most crucial hazards threatening worldwide health. Therefore, the early detection of COVID-19 is essential. The common way to detect COVID-19 is the reverse transcription-polymerase chain reaction (RT-PCR) test, although it has several drawbacks. Computed tomography (CT) scans can enable the early detection of suspected patients, however, the overlap between patterns of COVID-19 and other types of pneumonia makes it difficult for radiologists to diagnose COVID-19 accurately. On the other hand, deep learning (DL) techniques and especially the convolutional neural network (CNN) can classify COVID-19 and non-COVID-19 cases. In addition, DL techniques that use CT images can deliver an accurate diagnosis faster than the RT-PCR test, which consequently saves time for disease control and provides an efficient computer-aided diagnosis (CAD) system. The shortage of publicly available datasets of CT images, makes the CAD system's design a challenging task. The CAD systems in the literature are based on either individual CNN or two-fused CNNs; one used for segmentation and the other for classification and diagnosis. In this article, a novel CAD system is proposed for diagnosing COVID-19 based on the fusion of multiple CNNs. First, an end-to-end classification is performed. Afterward, the deep features are extracted from each network individually and classified using a support vector machine (SVM) classifier. Next, principal component analysis is applied to each deep feature set, extracted from each network. Such feature sets are then used to train an SVM classifier individually. Afterward, a selected number of principal components from each deep feature set are fused and compared with the fusion of the deep features extracted from each CNN. The results show that the proposed system is effective and capable of detecting COVID-19 and distinguishing it from non-COVID-19 cases with an accuracy of 94.7%, AUC of 0.98 (98%), sensitivity 95.6%, and specificity of 93.7%. Moreover, the results show that the system is efficient, as fusing a selected number of principal components has reduced the computational cost of the final model by almost 32%.

Project description:BackgroundThe rapid and accurate diagnosis of fractures is crucial for timely treatment of trauma patients. Deep learning, one of the most widely used forms of artificial intelligence (AI), is now commonly employed in medical imaging for fracture detection. This study aimed to construct a deep learning model using big data to recognize multiple-fracture X-ray images of extremity bones.MethodsRadiographic imaging data of extremities were retrospectively collected from five hospitals between January 2017 and September 2020. The total number of people finally included was 25,635 and the total number of images included was 26,098. After labeling the lesions, the randomized method used 90% of the data as the training set to develop the fracture detection model, and the remaining 10% was used as the validation set to verify the model. The faster region convolutional neural networks (R-CNN) algorithm was adopted to construct diagnostic models for detection. The Dice coefficient was used to evaluate the image segmentation accuracy. The performances of detection models were evaluated with sensitivity, specificity, and area under the receiver operating characteristic curve (AUC).ResultsThe free-response receiver operating characteristic (FROC) curve value was 0.886 and 0.843 for the detection of single and multiple fractures, respectively. Additionally, the effective identification AUC for all parts was higher than 0.920. Notably, the AUC for wrist fractures reached 0.952. The average accuracy in detecting bone fracture regions in the extremities was 0.865. When analyzing single and multiple lesions at the patient level, the sensitivity was 0.957 for patients with multiple lesions and 0.852 for those with single lesions. In the segmentation task, the training set (the data set used by the machine learning model to train and learn) and the validation set (the data set used to evaluate the performance of the model) reached 0.996 and 0.975, respectively.ConclusionsThe faster R-CNN training algorithm exhibits excellent performance in simultaneously identifying fractures in the hands, feet, wrists, ankles, radius and ulna, and tibia and fibula on X-ray images. It demonstrates high accuracy, low false-negative rates, and controllable false-positive rates. It can serve as a valuable screening tool.

Dataset Information

Multi-categorical deep learning neural network to classify retinal images: A pilot study employing small database.

Publications

Multi-categorical deep learning neural network to classify retinal images: A pilot study employing small database.

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