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Frizzled 8 promotes the cell proliferation and metastasis of renal cell carcinoma.


ABSTRACT: Recent reports have shown a rapid rise in the incidence of renal cell carcinoma (RCC), and Wnt (Wingless-related integration site) signaling pathway is important in RCC. Frizzled 8 (FZD8) is a member of Frizzled (FZD) receptor family which could activate canonical or non-canonical Wnt/?-catenin pathways. Nevertheless, the role of FZD8 in RCC is poorly investigated. The immunohistochemical analysis showed high expression of FZD8 in RCC tissues compared with peri-tumor tissues. FZD8 knockdown decreased the ability of proliferation and metastasis of RCC cells. Research revealed that the FZD8 regulated the transcription of Cyclin D1, c-Myc, and could promote the epithelial to mesenchymal transition (EMT) by mediating Vimentin and Snail through the Wnt/?-catenin signaling pathway. In addition, the results of our experiment revealed that FZD8 is involved in the regulation of non-canonical Wnt signaling pathway. These data suggested that the expression of FZD8 may play an important role in the proliferation and metastasis of RCC, and serve as a putative promising drug target for human RCC therapy.

SUBMITTER: Yang Q 

PROVIDER: S-EPMC5668014 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Frizzled 8 promotes the cell proliferation and metastasis of renal cell carcinoma.

Yang Qiwei Q   Wang Ye Y   Pan Xiuwu X   Ye Jianqing J   Gan Sishun S   Qu Fajun F   Chen Lu L   Chu Chuanmin C   Gao Yi Y   Cui Xingang X  

Oncotarget 20170908 45


Recent reports have shown a rapid rise in the incidence of renal cell carcinoma (RCC), and Wnt (Wingless-related integration site) signaling pathway is important in RCC. Frizzled 8 (FZD8) is a member of Frizzled (FZD) receptor family which could activate canonical or non-canonical Wnt/β-catenin pathways. Nevertheless, the role of FZD8 in RCC is poorly investigated. The immunohistochemical analysis showed high expression of FZD8 in RCC tissues compared with peri-tumor tissues. FZD8 knockdown decr  ...[more]

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