Ontology highlight
ABSTRACT:
SUBMITTER: Mills KF
PROVIDER: S-EPMC5668137 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Mills Kathryn F KF Yoshida Shohei S Stein Liana R LR Grozio Alessia A Kubota Shunsuke S Sasaki Yo Y Redpath Philip P Migaud Marie E ME Apte Rajendra S RS Uchida Koji K Yoshino Jun J Imai Shin-Ichiro SI
Cell metabolism 20161027 6
NAD<sup>+</sup> availability decreases with age and in certain disease conditions. Nicotinamide mononucleotide (NMN), a key NAD<sup>+</sup> intermediate, has been shown to enhance NAD<sup>+</sup> biosynthesis and ameliorate various pathologies in mouse disease models. In this study, we conducted a 12-month-long NMN administration to regular chow-fed wild-type C57BL/6N mice during their normal aging. Orally administered NMN was quickly utilized to synthesize NAD<sup>+</sup> in tissues. Remarkably ...[more]