Ontology highlight
ABSTRACT:
SUBMITTER: Boniecki MT
PROVIDER: S-EPMC5668364 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Boniecki Michal T MT Freibert Sven A SA Mühlenhoff Ulrich U Lill Roland R Cygler Miroslaw M
Nature communications 20171103 1
Iron-sulfur (Fe/S) clusters are essential protein cofactors crucial for many cellular functions including DNA maintenance, protein translation, and energy conversion. De novo Fe/S cluster synthesis occurs on the mitochondrial scaffold protein ISCU and requires cysteine desulfurase NFS1, ferredoxin, frataxin, and the small factors ISD11 and ACP (acyl carrier protein). Both the mechanism of Fe/S cluster synthesis and function of ISD11-ACP are poorly understood. Here, we present crystal structures ...[more]