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Research progress on the relationship between zinc deficiency, related microRNAs, and esophageal carcinoma.


ABSTRACT: Esophageal cancer (EC) is a common malignant tumor of the gastrointestinal tract with a high incidence in China. Zinc (Zn) deficiency is a key risk factor for the occurrence and development of EC and affects progression by regulating microRNA (miRNA, miR) expression. In addition, the dysregulation of miRNAs is accompanied by the dysregulation of their target genes in EC. In this paper, we review the potential molecular mechanisms between Zn deficiency and EC with the aim of providing new strategies and methods for early diagnosis, targeted therapy, and prognostic evaluation.

SUBMITTER: Liu CM 

PROVIDER: S-EPMC5668500 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Research progress on the relationship between zinc deficiency, related microRNAs, and esophageal carcinoma.

Liu Cong-Min CM   Liang Di D   Jin Jing J   Li Dao-Juan DJ   Zhang Ya-Chen YC   Gao Zhao-Yu ZY   He Yu-Tong YT  

Thoracic cancer 20170911 6


Esophageal cancer (EC) is a common malignant tumor of the gastrointestinal tract with a high incidence in China. Zinc (Zn) deficiency is a key risk factor for the occurrence and development of EC and affects progression by regulating microRNA (miRNA, miR) expression. In addition, the dysregulation of miRNAs is accompanied by the dysregulation of their target genes in EC. In this paper, we review the potential molecular mechanisms between Zn deficiency and EC with the aim of providing new strateg  ...[more]

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